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Clinical response and time to improvement with 308-nm excimer laser therapy in scarring alopecia: a retrospective cohort study.

MED

PurposeExcimer laser therapy, a 308-nm narrowband UV-B modality, has shown promise in inflammatory dermatoses, but remains understudied in scarring alopecia (SA).Materials and methodsWe conducted…

Assessing progress in gender-transformative sexual and reproductive health interventions: how does practice-based knowledge compare with published evidence in sub-Saharan Africa?

MED

BackgroundDiscriminatory gender norms and unequal power relations shape sexual and reproductive health (SRH) outcomes in sub-Saharan Africa. Yet, approaches to assessing progress in gender-transformative…

Warm intranasal saline irrigation reduces intraoperative blood loss during functional endoscopic sinus surgery: a propensity score-matched cohort study.

MED

BackgroundTo evaluate whether warm intranasal saline irrigation (38-40 °C) during functional endoscopic sinus surgery (FESS) is associated with reduced intraoperative bleeding compared with standard cold…

The impact of multiple long-term conditions on mortality, progression to kidney failure and health-related quality of life among people with chronic kidney disease: a multicentre cohort study (NURTuRE-CKD).

MED

BackgroundMultiple long-term conditions (MLTC) are common in people with chronic kidney disease (CKD). This study examined the impact of MLTC on mortality, CKD progression,…

Vitamin K status and vascular calcification biomarkers as determinants of carotid plaque in peritoneal dialysis: a prospective study.

MED

BackgroundVitamin K deficiency impairs the activation of calcification inhibitors such as matrix Gla protein, promoting vascular calcification in CKD. Protein induced by vitamin K…

Purinergic activity of circulating extracellular vesicles associates with disease progression in melanoma.

MED

Extracellular vesicles (EVs) produced by melanoma cells (MTEX) carry ecto-nucleotidases, CD39/CD73, on their surface membrane, produce adenosine (ADO), and deliver it to immune recipient…

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